Pieris Publication G. Matschiner, S. Huang, S. Constant, B. Rattenstetter, H. Gille, A.M. Hohlbaum, B.H. Koller, D. Keeling & M. Fitzgerald (2018) The Discovery and Development of AZD1402/PRS-060 a Potent and Selective Blocker of the IL-4 Receptor alpha
Pieris Publication Lutz Renders, Frank Dellanna, František Švára, Jitka Řehořová, Ondřej Viklický, Ming Wen, Matthias Braunisch, Karoline Meurer, Anne Maschek, Goran Martić, Kayti Aviano, Louis Matis, Ingmar Bruns. A Phase 2a Study to evaluate the safety, pharmacokinetics, and pharmacodynamics of repeated administrations of the hepcidin antagonist prs-080 over 4 weeks in anemic chronic kidney disease patients undergoing hemodialysis.
Pieris Publication Lutz Renders, Ming Wen, Frank Dellanna, Sven Heinrichs, Klemens Budde, Christian Rosenberger, Christiane Erley,Birgit Bader, Claudia Sommerer, Schaier, Matthias, Werner Feuerer, Edgar Fenzl, Rachel van Swelm, Dorine Swinkels, Klaus Kutz, Louis Matis, Ulrich Moebius, Safety, tolerability, and pharmacodynamics of the hepcidin antagonist PRS-080#022-DP after single administration – a phase Ib study in anemic chronic kidney disease patients undergoing hemodialysis
Pieris Publication Lutz Renders, Ming Wen, Frank Dellanna, Heinrichs, Sven, Klemens Budde, Christian Rosenberger, Christiane Erley, Birgit Bader, Claudia Sommerer, Schaier, Matthias, Werner Feuerer, Edgar Fenzl, Rachel van Swelm, Dorine Swinkels, Klaus Kutz, Louis Matis, Ulrich Moebius (2017) A phase Ib study investigating the safety, tolerability, pharmacokinetics, and pharmacodynamics of the hepcidin antagonist PRS-080#022-DP in anemic chronic kidney disease patients undergoing hemodialysis
Pieris Publication Hendrik Gille, Martin Hülsmeyer, Stefan Trentmann, Gabriele Matschiner, Hans Jürgen Christian, Todd Meyer, Ali Amirkhosravi, Laurent P. Audoly, Andreas M. Hohlbaum, Arne Skerra (2015) Functional characterization of a VEGF-A-targeting Anticalin, prototype of a novel therapeutic human protein class
Pieris Publication Marlon J. Hinner, Rachida-Siham Bel Aiba, Alexander Wiedenmann, Corinna Schlosser, Andrea Allersdorfer, Gabriele Matschiner, Christine Rothe, Ulrich Moebius, Shane A. Olwill (CRI 2015 Poster Presentation) Costimulatory T cell engagement via a novel bispecific anti-CD137/anti-HER2 protein based on Anticalin® technology
Pieris Publication Terwisscha van Scheltinga AG, Lub-de Hooge MN, Hinner MJ, Verheijen RB, Allersdorfer A, Hülsmeyer M, Nagengast WB, Schröder CP, Kosterink JG, de Vries EG, Audoly L, Olwill SA (2014) In Vivo Visualization of MET Tumor Expression and Anticalin Biodistribution with the MET-Specific Anticalin 89Zr-PRS-110 PET Tracer
Pieris Publication Gebauer M, Schiefner A, Matschiner G, Skerra A. (2013) Combinatorial design of an Anticalin directed against the extra-domain b for the specific targeting of oncofetal fibronectin
Pieris Publication Schönfeld, D., Matschiner, G., Chatwel,l L., Trentmann, S., Gille, H., Hülsmeyer, M., Brown, N., Kaye, P.M., Schlehuber, S., Hohlbaum, A.M., Skerra, A. (2009) An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies. PNAS 19;106(20):8198-203.
Pieris Publication Klaus Mross, Heike Richly, Richard Fischer, Dirk Scharr, Martin Büchert, Angelika Stern, Hendrik Gille, Laurent P. Audoly, Max E. Scheulen (2013) First-in-Human Phase I Study of PRS-050 (Angiocal), an Anticalin Targeting and Antagonizing VEGF-A, in Patients with Advanced Solid Tumors
